*Denotes Corresponding Author(s);
2022
(33) Skeens, E.; Pantouris, G.; Shah, D.; Manjula, R.; Ombrello, M.J.; Maluf, N.K.; Bhandari, V.; Lisi, G.P.*; Lolis, E.J.* "A Cysteine Variant at an Allosteric Site Alters MIF Dynamics and Biological Function in Homo- and Heterotrimeric Assemblies" Frontiers in Molecular Biosciences. 2022. DOI: 10.3389/fmolb.2022.783669 (ES and GP contributed equally)
2021
(32) Nierzwicki, L.; East, K.W.; Morzan, U.N.; Arantes, P.R.; Batista, V.S.; Lisi, G.P.*; Palermo, G.* "Enhanced Specificity Mutations Perturb Allosteric Signaling in CRISPR-Cas9" eLife. 2021. DOI: 10.7554.eLife.73601 (LN and KWE contributed equally)
(31) Belato, H.B.; D'Ordine, A.M.; Nierzwicki, L.; Arantes, P.R.; Jogl, G.; Palermo, G.*; Lisi, G.P.* "Structural and Dynamic Insight into the HNH Domain of Divergent Cas9 Species" Journal of Structural Biology. 2021. 214. 107814-107824
(30) Cui, J.Y.; Lisi, G.P.* "Molecular Level Insights into the Structural and Dynamic Factors Driving Cytokine Function" Frontiers in Molecular Biosciences. 2021. DOI: 10.3389/fmolb.2021.773252
(29) Skeens, E.; Gadzuk-Shea, M.M.; Shah, D.; Bhandari, V.; Schweppe, D.K.; Berlow, R.B.*; Lisi, G.P.* "Redox-dependent Structure and Dynamics of Macrophage Migration Inhibitory Factor Reveal Sites of Latent Allostery" bioRxiv. 2021. DOI: 10.1101/2021.09.01.458630
(28) Parkins, A.; Skeens, E.; McCallum, C.M.; Lisi, G.P.*; Pantouris, G.* "The N-terminus of MIF Regulates the Dynamic Profile of Residues Involved in CD74 Activation" Biophysical Journal. 2021. 120. 1-8
(27) Chen, E.; Reiss, K.; Shah, D.; Manjula, R.; Allen, B.; Murphy, E.L.; Murphy, J.W.; Batista, V.S.; Bhandari, V.; Lolis, E.J.*; Lisi, G.P.* "A Structurally Preserved Allosteric Site in the MIF Superfamily Affects Enzymatic Activity and CD74 Activation in D-dopachrome Tautomerase" Journal of Biological Chemistry. 2021. 297. 101061-101073
(26) Wang, J.*; Reiss, K.; Shi, Y.; Lolis, E.; Lisi, G.P.; Batista, V.S.* "Mechanism of Inhibition of the Reproduction of SARS-CoV-2 and Ebola Viruses by Remdesivir" Biochemistry. 2021. 60. 1869-1875
(25) East, K.W.; Delaglio, F.; Lisi, G.P.* “A Simple Approach for Reconstruction of Non-uniformly Sampled Pseudo-3D NMR Data for Accurate Measurement of Spin Relaxation Parameters" Journal of Biomolecular NMR. 2021. 75. 213-219
2020
(24) Skeens, E.; East, K.W.; Lisi, G.P.* “1H, 13C, 15N Backbone Resonance Assignment of the Recognition Lobe Subdomain 3 (Rec3) from Streptococcus pyogenes CRISPR-Cas9" Biomolecular NMR Assignments. 2020. 15. 25-28
(23) Cui, J.Y.; Zhang, F.; Nierzwicki, L.; Palermo, G.; Linhardt, R.J.; Lisi, G.P.* “Mapping the Structural and Dynamic Determinants of pH-sensitive Heparin Binding to Granulocyte Macrophage-colony Stimulating Factor" Biochemistry. 2020. 59. 3541-3553
(22) Murphy, J.W.; Rajasekaran, D.; Merkel, J.; Skeens, E.; Keeler, C.; Hodsdon, M.; Lisi, G.P.; Lolis, E.J.* “High-throughput Screening of a Functional Human CXCL12-CXCR4 Signaling Axis in a Genetically Modified S. cerevisiae: Discovery of a Novel Up-regulator of CXCR4 Activity" Frontiers in Molecular Biosciences. 2020. 7. DOI: 10.389/fmolb.2020.00164
(21) Pantouris, G.*; Khurana, L.; Ma, A.; Skeens, E.; Reiss, K.; Batista, V.S.; Lisi, G.P.*; Lolis, E.J.* “Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel" Cell Chemical Biology. 2020. 27. 740-750
(20) East, K.W.; Newton, J.C.; Morzan, U.N.; Narkhede, Y.; Acharya, A.; Skeens, E.; Jogl, G.; Batista, V.S.; Palermo, G.*; Lisi, G.P.* “Allosteric Motions of the CRISPR-Cas9 HNH Nuclease Probed by NMR and Molecular Dynamics” Journal of the American Chemical Society. 2020. 142. 1348-1358
- Highlighted in "Allosteric Control of Enzyme Activity: From Ancient Origins to Recent Genome-editing Technologies" Biochemistry 2020
- Included in JACS 2020 virtual issue dedicated to outstanding early career investigators
(19) East, K.W.; Skeens, E.; Cui, J.Y.; Belato, H.B.; Mitchell, B.; Hsu, R.; Batista, V.S.; Palermo, G.; Lisi, G.P.* “NMR and Computational Methods for Molecular Resolution of Allosteric Pathways in Enzyme Complexes” Biophysical Reviews. 2020. 12. 155-174
2019
(18) East, K.W.; Leith, A.; Ragavendran, A.; Delaglio, F.; Lisi, G.P.* “NMRdock: Lightweight and Modular NMR Processing” bioRxiv. 2019. DOI: 10.1101/679688
(17) Belato, H.B.; East, K.W.; Lisi, G.P.* “1H, 13C, 15N Backbone and Side Chain Resonance Assignments of the HNH Nuclease from Streptococcus pyogenes CRISPR-Cas9” Biomolecular NMR Assignments. 2019. 13. 367-370 (HBB and KWE contributed equally)
2018
(16) Negre, C.F.A.*; Morzan, U.N.*; Hendrickson, H.P.; Pal, R.; Lisi, G.P.; Loria, J.P.; Rivalta, I.*; Batista, V.S.* “Eigenvector Centrality for Characterization of Protein Allosteric Pathways” Proceedings of the National Academy of Sciences, USA. 2018. 115. E12201-E12208
(15) Lisi, G.P.; Currier, A.A.; Loria, J.P.* “Glutamine Hydrolysis by Imidazole Glycerol Phosphate Synthase Displays Temperature-Dependent Allosteric Activation” Frontiers in Molecular Biosciences. 2018. 5. DOI: 10.3389/fmolb.2018.0004
2017
(14) Lisi, G.P.*; Loria, J.P.* “Allostery in Enzyme Catalysis” Current Opinion in Structural Biology. 2017. 47. 123-130 (Thematic Issue on Catalysis and Regulation)
(13) Lisi, G.P.; East, K.W.; Batista, V.S.; Loria, J.P.* “Altering the Allosteric Pathway in IGPS Suppresses Millisecond Motions and Catalytic Activity” Proceedings of the National Academy of Sciences, USA. 2017. 114. E3414-E3423
2016
(12) Rivalta, I.*; Lisi, G.P.; Snoeberger, N.-S.; Manley, G.A.; Loria, J.P.*; Batista, V.S.* “Allosteric Communication Disrupted by a Small Molecule Binding to the Imidazole Glycerol Phosphate Synthase Protein-Protein Interface” Biochemistry. 2016. 55. 6484-6494
(11) Lisi, G.P.; Hughes, R.P.; Wilcox, D.E.* “Coordination Contributions to Protein Stability in Metal-Substituted Carbonic Anhydrase” Journal of Biological Inorganic Chemistry. 2016. 21. 659-667
(10) Lisi, G.P.; Manley, G.A.; Hendrickson, H.; Rivalta, I.; Batista, V.S.; Loria, J.P.* “Dissecting Dynamic Allosteric Pathways using Chemically Related Small Molecule Activators” Structure. 2016. 24. 1155-1166 (Feature Article)
(9) Lisi, G.P.*; Loria, J.P.* “Solution NMR Spectroscopy for the Study of Enzyme Allostery” Chemical Reviews. 2016. 116. 6323-6369 (Thematic Issue on Protein Ensembles and Allostery)
(8) Lisi, G.P.; Loria, J.P.* “Using NMR Spectroscopy to Elucidate the Role of Molecular Motions in Enzyme Function” Progress in NMR Spectroscopy. 2016. 92-93. 1-17
2015
(7) Amacher, J.F.; Zhong, F.; Lisi, G.P.; Zhu, M.Q.; Alden, S.L.; Hoke, K.H.; Madden, D.R.; Pletneva, E.V.* “A Compact Structure of Cytochrome c Trapped in a Lysine-Ligated State: Loop Refolding and Functional Implications of a Conformational Switch” Journal of the American Chemical Society. 2015. 137. 8435-8449
2014
(6) Lisi, G.P.; Png, C.Y.M.; Wilcox, D.E.* “Thermodynamic Contributions to the Stability of the Insulin Hexamer” Biochemistry. 2014. 53. 3576-3584
(5) Zhong, F.; Lisi, G.P.; Collins, D.P.; Dawson, J.H.; Pletneva, E.V.* “Redox-Dependent Stability, Protonation, and Reactivity of Cysteine-Bound Heme Proteins.” Proceedings of the National Academy of Sciences, USA. 2014. 111. E306-E315
2012
(4) Harper-Leatherman, A.S.*; Iftikhar, M.; Ndoi, A.; Scappaticci, S.J.; Lisi, G.P.; Buzard, K.L.; Garvey, E.M. “Simplified Procedure for Encapsulating Cytochrome c in Silica Aerogel Nanoarchitectures While Retaining Gas-Phase Bioactivity.” Langmuir. 2012. 28. 14756-14765
(3) Miecznikowski, J.R.*; Lo, W.; Lynn, M.A.; Jain, S.; Keilich, L.C.; Kloczko, N.F.; O’Loughlin, B.E.; DiMarzio, A.P.; Foley, K.M.; Lisi, G.P.; Kwiecien, D.J.; Butrick, E.E.; Powers, E.; Al-Abbasee, R. “Syntheses, Characterization, Density Functional Theory Calculations and Activity of Tridentate SNS Zinc Pincer Complexes Based on Bis-Imidazole or Bis-Triazole Precursors.” Inorganica Chimica Acta. 2012. 387. 25-36
2011
(2) Miecznikowski, J.R.*; Lo, W.; Lynn, M.A.; O’Loughlin, B.E.; DiMarzio, A.P.; Martinez, A.M.; Lampe, L.; Foley, K.M.; Keilich, L.C.; Lisi, G.P.; Kwiecien, D.J.; Pires, C.M.; Kelly, W.J.; Kloczko, N.F.; Morio, K.N. “Syntheses, Characterization, Density Functional Theory Calculations and Activity of Tridentate SNS Zinc Pincer Complexes.” Inorganica Chimica Acta. 2011. 376. 515-524
(1) Miecznikowski, J.R.*; Caradonna, J.P.; Foley, K.M.; Kwiecien, D.J.; Lisi, G.P.; Martinez, A.M. “Introduction to Homogenous Catalysis with Ruthenium-Catalyzed Oxidation of Alcohols: An Experiment for Undergraduate Advanced Inorganic Chemistry Students.” Journal of Chemical Education. 2011. 88. 657-661
2022
(33) Skeens, E.; Pantouris, G.; Shah, D.; Manjula, R.; Ombrello, M.J.; Maluf, N.K.; Bhandari, V.; Lisi, G.P.*; Lolis, E.J.* "A Cysteine Variant at an Allosteric Site Alters MIF Dynamics and Biological Function in Homo- and Heterotrimeric Assemblies" Frontiers in Molecular Biosciences. 2022. DOI: 10.3389/fmolb.2022.783669 (ES and GP contributed equally)
2021
(32) Nierzwicki, L.; East, K.W.; Morzan, U.N.; Arantes, P.R.; Batista, V.S.; Lisi, G.P.*; Palermo, G.* "Enhanced Specificity Mutations Perturb Allosteric Signaling in CRISPR-Cas9" eLife. 2021. DOI: 10.7554.eLife.73601 (LN and KWE contributed equally)
(31) Belato, H.B.; D'Ordine, A.M.; Nierzwicki, L.; Arantes, P.R.; Jogl, G.; Palermo, G.*; Lisi, G.P.* "Structural and Dynamic Insight into the HNH Domain of Divergent Cas9 Species" Journal of Structural Biology. 2021. 214. 107814-107824
(30) Cui, J.Y.; Lisi, G.P.* "Molecular Level Insights into the Structural and Dynamic Factors Driving Cytokine Function" Frontiers in Molecular Biosciences. 2021. DOI: 10.3389/fmolb.2021.773252
(29) Skeens, E.; Gadzuk-Shea, M.M.; Shah, D.; Bhandari, V.; Schweppe, D.K.; Berlow, R.B.*; Lisi, G.P.* "Redox-dependent Structure and Dynamics of Macrophage Migration Inhibitory Factor Reveal Sites of Latent Allostery" bioRxiv. 2021. DOI: 10.1101/2021.09.01.458630
(28) Parkins, A.; Skeens, E.; McCallum, C.M.; Lisi, G.P.*; Pantouris, G.* "The N-terminus of MIF Regulates the Dynamic Profile of Residues Involved in CD74 Activation" Biophysical Journal. 2021. 120. 1-8
(27) Chen, E.; Reiss, K.; Shah, D.; Manjula, R.; Allen, B.; Murphy, E.L.; Murphy, J.W.; Batista, V.S.; Bhandari, V.; Lolis, E.J.*; Lisi, G.P.* "A Structurally Preserved Allosteric Site in the MIF Superfamily Affects Enzymatic Activity and CD74 Activation in D-dopachrome Tautomerase" Journal of Biological Chemistry. 2021. 297. 101061-101073
(26) Wang, J.*; Reiss, K.; Shi, Y.; Lolis, E.; Lisi, G.P.; Batista, V.S.* "Mechanism of Inhibition of the Reproduction of SARS-CoV-2 and Ebola Viruses by Remdesivir" Biochemistry. 2021. 60. 1869-1875
(25) East, K.W.; Delaglio, F.; Lisi, G.P.* “A Simple Approach for Reconstruction of Non-uniformly Sampled Pseudo-3D NMR Data for Accurate Measurement of Spin Relaxation Parameters" Journal of Biomolecular NMR. 2021. 75. 213-219
2020
(24) Skeens, E.; East, K.W.; Lisi, G.P.* “1H, 13C, 15N Backbone Resonance Assignment of the Recognition Lobe Subdomain 3 (Rec3) from Streptococcus pyogenes CRISPR-Cas9" Biomolecular NMR Assignments. 2020. 15. 25-28
(23) Cui, J.Y.; Zhang, F.; Nierzwicki, L.; Palermo, G.; Linhardt, R.J.; Lisi, G.P.* “Mapping the Structural and Dynamic Determinants of pH-sensitive Heparin Binding to Granulocyte Macrophage-colony Stimulating Factor" Biochemistry. 2020. 59. 3541-3553
(22) Murphy, J.W.; Rajasekaran, D.; Merkel, J.; Skeens, E.; Keeler, C.; Hodsdon, M.; Lisi, G.P.; Lolis, E.J.* “High-throughput Screening of a Functional Human CXCL12-CXCR4 Signaling Axis in a Genetically Modified S. cerevisiae: Discovery of a Novel Up-regulator of CXCR4 Activity" Frontiers in Molecular Biosciences. 2020. 7. DOI: 10.389/fmolb.2020.00164
(21) Pantouris, G.*; Khurana, L.; Ma, A.; Skeens, E.; Reiss, K.; Batista, V.S.; Lisi, G.P.*; Lolis, E.J.* “Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel" Cell Chemical Biology. 2020. 27. 740-750
(20) East, K.W.; Newton, J.C.; Morzan, U.N.; Narkhede, Y.; Acharya, A.; Skeens, E.; Jogl, G.; Batista, V.S.; Palermo, G.*; Lisi, G.P.* “Allosteric Motions of the CRISPR-Cas9 HNH Nuclease Probed by NMR and Molecular Dynamics” Journal of the American Chemical Society. 2020. 142. 1348-1358
- Highlighted in "Allosteric Control of Enzyme Activity: From Ancient Origins to Recent Genome-editing Technologies" Biochemistry 2020
- Included in JACS 2020 virtual issue dedicated to outstanding early career investigators
(19) East, K.W.; Skeens, E.; Cui, J.Y.; Belato, H.B.; Mitchell, B.; Hsu, R.; Batista, V.S.; Palermo, G.; Lisi, G.P.* “NMR and Computational Methods for Molecular Resolution of Allosteric Pathways in Enzyme Complexes” Biophysical Reviews. 2020. 12. 155-174
2019
(18) East, K.W.; Leith, A.; Ragavendran, A.; Delaglio, F.; Lisi, G.P.* “NMRdock: Lightweight and Modular NMR Processing” bioRxiv. 2019. DOI: 10.1101/679688
(17) Belato, H.B.; East, K.W.; Lisi, G.P.* “1H, 13C, 15N Backbone and Side Chain Resonance Assignments of the HNH Nuclease from Streptococcus pyogenes CRISPR-Cas9” Biomolecular NMR Assignments. 2019. 13. 367-370 (HBB and KWE contributed equally)
2018
(16) Negre, C.F.A.*; Morzan, U.N.*; Hendrickson, H.P.; Pal, R.; Lisi, G.P.; Loria, J.P.; Rivalta, I.*; Batista, V.S.* “Eigenvector Centrality for Characterization of Protein Allosteric Pathways” Proceedings of the National Academy of Sciences, USA. 2018. 115. E12201-E12208
(15) Lisi, G.P.; Currier, A.A.; Loria, J.P.* “Glutamine Hydrolysis by Imidazole Glycerol Phosphate Synthase Displays Temperature-Dependent Allosteric Activation” Frontiers in Molecular Biosciences. 2018. 5. DOI: 10.3389/fmolb.2018.0004
2017
(14) Lisi, G.P.*; Loria, J.P.* “Allostery in Enzyme Catalysis” Current Opinion in Structural Biology. 2017. 47. 123-130 (Thematic Issue on Catalysis and Regulation)
(13) Lisi, G.P.; East, K.W.; Batista, V.S.; Loria, J.P.* “Altering the Allosteric Pathway in IGPS Suppresses Millisecond Motions and Catalytic Activity” Proceedings of the National Academy of Sciences, USA. 2017. 114. E3414-E3423
2016
(12) Rivalta, I.*; Lisi, G.P.; Snoeberger, N.-S.; Manley, G.A.; Loria, J.P.*; Batista, V.S.* “Allosteric Communication Disrupted by a Small Molecule Binding to the Imidazole Glycerol Phosphate Synthase Protein-Protein Interface” Biochemistry. 2016. 55. 6484-6494
(11) Lisi, G.P.; Hughes, R.P.; Wilcox, D.E.* “Coordination Contributions to Protein Stability in Metal-Substituted Carbonic Anhydrase” Journal of Biological Inorganic Chemistry. 2016. 21. 659-667
(10) Lisi, G.P.; Manley, G.A.; Hendrickson, H.; Rivalta, I.; Batista, V.S.; Loria, J.P.* “Dissecting Dynamic Allosteric Pathways using Chemically Related Small Molecule Activators” Structure. 2016. 24. 1155-1166 (Feature Article)
(9) Lisi, G.P.*; Loria, J.P.* “Solution NMR Spectroscopy for the Study of Enzyme Allostery” Chemical Reviews. 2016. 116. 6323-6369 (Thematic Issue on Protein Ensembles and Allostery)
(8) Lisi, G.P.; Loria, J.P.* “Using NMR Spectroscopy to Elucidate the Role of Molecular Motions in Enzyme Function” Progress in NMR Spectroscopy. 2016. 92-93. 1-17
2015
(7) Amacher, J.F.; Zhong, F.; Lisi, G.P.; Zhu, M.Q.; Alden, S.L.; Hoke, K.H.; Madden, D.R.; Pletneva, E.V.* “A Compact Structure of Cytochrome c Trapped in a Lysine-Ligated State: Loop Refolding and Functional Implications of a Conformational Switch” Journal of the American Chemical Society. 2015. 137. 8435-8449
2014
(6) Lisi, G.P.; Png, C.Y.M.; Wilcox, D.E.* “Thermodynamic Contributions to the Stability of the Insulin Hexamer” Biochemistry. 2014. 53. 3576-3584
(5) Zhong, F.; Lisi, G.P.; Collins, D.P.; Dawson, J.H.; Pletneva, E.V.* “Redox-Dependent Stability, Protonation, and Reactivity of Cysteine-Bound Heme Proteins.” Proceedings of the National Academy of Sciences, USA. 2014. 111. E306-E315
2012
(4) Harper-Leatherman, A.S.*; Iftikhar, M.; Ndoi, A.; Scappaticci, S.J.; Lisi, G.P.; Buzard, K.L.; Garvey, E.M. “Simplified Procedure for Encapsulating Cytochrome c in Silica Aerogel Nanoarchitectures While Retaining Gas-Phase Bioactivity.” Langmuir. 2012. 28. 14756-14765
(3) Miecznikowski, J.R.*; Lo, W.; Lynn, M.A.; Jain, S.; Keilich, L.C.; Kloczko, N.F.; O’Loughlin, B.E.; DiMarzio, A.P.; Foley, K.M.; Lisi, G.P.; Kwiecien, D.J.; Butrick, E.E.; Powers, E.; Al-Abbasee, R. “Syntheses, Characterization, Density Functional Theory Calculations and Activity of Tridentate SNS Zinc Pincer Complexes Based on Bis-Imidazole or Bis-Triazole Precursors.” Inorganica Chimica Acta. 2012. 387. 25-36
2011
(2) Miecznikowski, J.R.*; Lo, W.; Lynn, M.A.; O’Loughlin, B.E.; DiMarzio, A.P.; Martinez, A.M.; Lampe, L.; Foley, K.M.; Keilich, L.C.; Lisi, G.P.; Kwiecien, D.J.; Pires, C.M.; Kelly, W.J.; Kloczko, N.F.; Morio, K.N. “Syntheses, Characterization, Density Functional Theory Calculations and Activity of Tridentate SNS Zinc Pincer Complexes.” Inorganica Chimica Acta. 2011. 376. 515-524
(1) Miecznikowski, J.R.*; Caradonna, J.P.; Foley, K.M.; Kwiecien, D.J.; Lisi, G.P.; Martinez, A.M. “Introduction to Homogenous Catalysis with Ruthenium-Catalyzed Oxidation of Alcohols: An Experiment for Undergraduate Advanced Inorganic Chemistry Students.” Journal of Chemical Education. 2011. 88. 657-661
